منابع مشابه
Appraisal of antihypertensive drug therapy.
SUMMARY Four completed prospective studies of drug-treated and control hypertensives utilizing double blind ran-domized protocols are reviewed for the purpose of evaluating the evidence on which the present therapeutic crusade is based. Patients studied were predominantly male, observed for short period, had complications or died at young age, had high incidence of previous target organ vascula...
متن کاملRebuttal: appraisal of antihypertensive drug therapy.
DR. HERBERT CHASIS has long been known for his skepticism with respect to the treatment of hypertension. Indeed, it was the skepticism of Drs. Goldring, Chasis and Perera which served as an important stimulus in planning the Veterans Administration Cooperative Study. Dr. Chasis completely rejects the concept that the cardiovascular damage seen in hypertension is the consequence of the elevated ...
متن کاملAntagonism of antihypertensive drug therapy by nonsteroidal anti-inflammatory drugs.
Certain nonsteroidal anti-inflammatory drugs antagonize the action of antihypertensive therapy. Indomethacin has been shown to abrogate the antihypertensive effect of beta-adrenergic receptor blockers, diuretics, converting enzyme inhibitors, and several antihypertensive drug combinations, and the accumulated evidence on piroxicam indicates that it also raises arterial pressure in treated patie...
متن کاملDifferential effects of antihypertensive drug therapy on arterial compliance.
Although vascular compliance, deltaV/deltaP, is abnormal in essential hypertension and can be improved by antihypertensive drug therapy, it is not clear whether drug-induced changes in compliance are attributable solely to lower achieved blood pressure (BP), and thus equally likely with different drugs possessing similar antihypertensive efficacy. Therefore, we used computerized arterial pulse ...
متن کاملAntihypertensive Drug Therapy in Consideration of Circadian Blood Pressure Variation*
J-MUBA was a large-scale clinical study which, for the first time in the world, evaluated the effects of an antihypertensive drug on circadian BP variation in more than 600 patients with hypertension. Although ACE inhibitors reportedly exert equal 24-hour antihypertensive effects on daytime and nighttime BP, and -blockers are reported to have weaker effects on nighttime BP than on daytime BP. H...
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ژورنال
عنوان ژورنال: Circulation
سال: 1974
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.50.1.4